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Cytochrome P450 (CYP) pathway of eicosanoid metabolism and its relevance in inflammation. Nomenclature: Simplified scheme of polyenioic fatty acid metabolism via the cytochrome P450 (CYP) pathway leading to the formation of anti- and pro-inflammatory mediators. Common abbreviations are bold, followed by the common trivial names (if available) and (if available) by the name in accordance to the International Union of Pure and Applied Chemistry (IUPAC): ω-3-PUFAs N-3 polyunsaturated fatty acid; ALA α-linolenic acid, (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid; ETA eicosatetraenoic acid, all-cis-8,11,14,17-eicosatetraenoic acid; EPA eicosapentaenoic acid, (5Z,8Z,11Z,14Z,17Z)-eicosa- 5,8,11,14,17-pentenoic acid; DPA docosapentaenoic acid, 7,10,13,16,19-docosapentaenoic acid; DHA docosahexaenoic acid, (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid; ω-6-PUFAs N-6 polyunsaturated fatty acid; LA linoleic acid, cis, cis-9,12-octadecadienoic acid; DGLA dihomo gamma-linolenic acid, (8Z,11Z,14Z)-8,11,14-Icosatrienoic acid; AA archidonic acid, (5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenoic acid; DTA docosatetranoic acid, (7Z,10Z,13Z,16Z)-7,10,13,16-docosatetraenoic acid; BDPA osbond acid, (All-Z)-4,7,10,13,16-docosapentaenoic acid; AT-Cox2 aspirin-triggered cyclooxygenase 2; CYP* cytochrome P450 isoforms; 18-HpEPE 18-hydroxyeicosapentaenoic acid, 18-hydroxyicosa-2,4,6,8,10-pentaenoic acid; 18-HEPE (5Z,8Z,11Z,14Z,16E)-18-hydroxyicosa-5,8,11,14,16-pentaenoic acid; RvE1 resolvin E1, (5S,6Z,8E,10E,12R,14Z,16E,18R)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid; RvE2 resolvin E2, (5S,6E,8Z,11Z,14Z,16E,18R)-5,18-dihydroxyicosa-6,8,11,14,16-pentaenoic acid; RvE3 resolvin E3, (5Z,8Z,11Z,13E,15E,18S)-17,18-dihydroxyicosa-5,8,11,13,15-pentaenoic acid; Cox cyclooxygenase; 20-HETE 20-hydroxyeicosatetraenoic acid, (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid; 20-OH-PGE2 20-hydroxy prostaglandin E2; 20-COOH-HETE 20-carboxy-hydroxyeicosatetraenoic acid; EETs epoxyeicosatrienoic acid; sEH soluble epoxide hydrolase; DHETs dihydroxyeicosatrienoic acids.

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