When hypoalbuminemia and acute pancreatitis coexist, a degradation cycle comes into play. Intravascular proteases digest serum albumin and induce blood vessel leakage. Serum-origin proteases migrate into the interstitial space. Trypsin, in particular, serves as activator of pancreas-origin proteases, lipases and amylases. In-pancreatic activation of digestive enzymes damages pancreatic tissues and attacks vasculature from the interstitial space, allowing passage of even more destructive proteases into the serum. Systemic impacts include distribution of digestive enzymes throughout the vascular system and denial of nutrition.