Download original image
The shortcomings of existing drug discovery for protease inhibitors give rise to products such as nelfinavir, a putative HIV protease inhibitor. Nelfinavir is now known to induce acute pancreatitis and this work demonstrates that it promotes digestion of serum proteins, especially serum albumin, by digestive proteases. A diagnostic for acute pancreatitis demonstrates the presence of digestive enzymes in the serum. Taken together, it is postulated that the unspecified “catabolism” driver for hypoalbuminemia is proteolysis. The relative benefits of ESRSL for drug screening and potential use in the clinic are shown.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.