New publication – "Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer”"

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Published on 02 October 2019

We are pleased to share the publication of a new article in 4open "Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer”" by Björn L.D.M. Brücher and Ijaz S. Jamall. The synopsis concludes the open access special issue guest edited by Obul R. Bandapalli.

In this special issue, the authors set out to challenge established thinking on cancer and present a new cancer paradigm which “…provides compelling evidence that carcinogenesis is explained by a six-step sequence of events for the vast majority of cancers.”

Writing in the synopsis, the authors argue that, in the vast majority of cancers, carcinogenesis cannot be explained simply by mutations, radiation, epigenetics, stem cells and the Warburg effect. “Our paradigm, though more complex, is more reliable and plausible. It states that cancer originates from a disruption of homeostasis.”

They go on to argue “This paradigm provides opportunities to move away from a symptom-oriented understanding of cancer and is much closer to a cause-based understanding, which opens the door for early preventative strategies to mitigate cancer as a disease, and to interdict metastases.”

By helping to shift the focus in cancer research to understanding the causes rather than treating the symptoms of cancer, the authors hope to help identify the root cause(s) of around 80% of sporadic cancers and offset some of the significant expenditure on symptomatic therapies and symptom-orientated cancer research. The authors conclude “We are hopeful that our thinking and scientific work stimulates further thinking in cancer and ultimately leads to benefits for those who deserve it the most: cancer patients and their relatives.”

Read the article "Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer”"

Browse the complete special issue

Read the ‘Key summaries’ article providing a non-technical overview of the special issue - “New research challenges current thinking on cancer”

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