Download original image
Canonical NF-κB signaling pathway. Simplified scheme of the canonical NF-κB pathway. Nomenclature: TNFα: tumor necrosis factor α; TNFR1: tumor necrosis factor receptor 1; IL-1: interleukin 1; ILR1: interleukin 1 receptor; LPS: lipopolysacharide; TLR4: toll-like receptor 4; IKK complex: IκB kinase enzyme complex to upregulate the NF-κB signaling; IκBα: IκB kinase 1 (IKK1); IκBβ: IκB kinase 2 (IKK2); IκBγ: IκB kinase gamma; NEMO: NF-kappa-B essential modulator, regulatory scaffolding protein; P: phosphorylated; Akt: protein kinase B (PBK); p65: NF-κB3 (RelA); c-Rel: proto-oncogene NF-κB transcription factor; p50: NF-κB1 (progenitor is p105). Canonical NF-κB-IKK-complex is the inactive cytoplasmic form, consisting out of IκBα, p65 and p50. The canonical NF-κB heterodimer is the active form entering into the nucleus consisting out of p65 and p50
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.