Open Access

Figure 3


Download original image

Graphical representation of the effect of various mitochondrial gene therapeutic approaches on mitochondrial heteroplasmy. A cell can go from homoplasmic wild type (dark Green) to homoplasmic mutant (dark ochre) and pass stages of heteroplasmy where either wild type (light green) or mutant (light ochre) mtDNA is dominant. The threshold determines the transition from normal phenotype to mutant phenotype. Ovals represent therapeutic intervention and rectangles represent natural processes. Arrows that do not contact the DNA boxes indicate that the process does not change the ratio or content of DNA. Figure recreated based on a corresponding figure in [145].

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.