Open Access

Table 1

Top 10 enzymes involved in aging having maximum interactions.

Entrez GeneID Entrez Gene Name Entrez gene description EC number Expression Degree of interaction logFC adj.P.Val Localization
4215 MAP3K3 mitogen-activated protein kinase kinasekinase 3 2.7.11.25 up 179 0.034 1.53E-03 cytoplasm
10856 RUVBL2 RuvB-like 2 (E. coli) 3.6.4.12 down 168 −0.014 5.09E-04 nucleus
7052 TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 2.3.2.13 up 89 0.062 7.37E-04 cytoplasm
9734 HDAC9 histone deacetylase 9 3.5.1.98 down 49 −0.036 2.93E-04 nucleus
2289 FKBP5 FK506 binding protein 5 5.2.1.8 up 37 0.085 1.22E-04 cytoplasm
4751 NEK2 NIMA (never in mitosis gene a)-related kinase 2 2.7.11.1 down 32 −0.080 1.53E-03 cytoplasm
78990 OTUB2 OTU domain, ubiquitin aldehyde binding 2 3.4.19.12 down 25 −0.046 1.06E-03 cytoplasm
2870 GRK6 G protein-coupled r eptor kinase 6 2.7.11.16 down 23 −0.020 1.41E-03 nucleus
84937 ZNRF1 zinc and ring finger 1 6.3.2.- down 16 −0.037 2.88E-04 endoplasmic reticulum membrane
29116 MYLIP myosin regulatory light chain interacting protein 6.3.2.- down 14 −0.020 7.28E-04 cytoplasm

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