Open Access
Table 1
Top 10 enzymes involved in aging having maximum interactions.
| Entrez GeneID | Entrez Gene Name | Entrez gene description | EC number | Expression | Degree of interaction | logFC | adj.P.Val | Localization |
|---|---|---|---|---|---|---|---|---|
| 4215 | MAP3K3 | mitogen-activated protein kinase kinasekinase 3 | 2.7.11.25 | up | 179 | 0.034 | 1.53E-03 | cytoplasm |
| 10856 | RUVBL2 | RuvB-like 2 (E. coli) | 3.6.4.12 | down | 168 | −0.014 | 5.09E-04 | nucleus |
| 7052 | TGM2 | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 2.3.2.13 | up | 89 | 0.062 | 7.37E-04 | cytoplasm |
| 9734 | HDAC9 | histone deacetylase 9 | 3.5.1.98 | down | 49 | −0.036 | 2.93E-04 | nucleus |
| 2289 | FKBP5 | FK506 binding protein 5 | 5.2.1.8 | up | 37 | 0.085 | 1.22E-04 | cytoplasm |
| 4751 | NEK2 | NIMA (never in mitosis gene a)-related kinase 2 | 2.7.11.1 | down | 32 | −0.080 | 1.53E-03 | cytoplasm |
| 78990 | OTUB2 | OTU domain, ubiquitin aldehyde binding 2 | 3.4.19.12 | down | 25 | −0.046 | 1.06E-03 | cytoplasm |
| 2870 | GRK6 | G protein-coupled r eptor kinase 6 | 2.7.11.16 | down | 23 | −0.020 | 1.41E-03 | nucleus |
| 84937 | ZNRF1 | zinc and ring finger 1 | 6.3.2.- | down | 16 | −0.037 | 2.88E-04 | endoplasmic reticulum membrane |
| 29116 | MYLIP | myosin regulatory light chain interacting protein | 6.3.2.- | down | 14 | −0.020 | 7.28E-04 | cytoplasm |