Volume 5, 2022
|Number of page(s)||27|
|Section||Life Sciences - Medicine|
|Published online||28 January 2022|
Recent developments in mitochondrial medicine (part 2)
Aging, longevity and microbiota
Midwestern University, College of Pharmacy, Department of Pharmaceutical Sciences, 19555 N. 59th Avenue, Glendale, AZ 85308, USA
2 Université de Paris, INSERM U1016, Institut Cochin, CNRS UMR8104, Faculté de Médecine Cochin-Port Royal, 75014 Paris, France
3 Laboratory of Excellence GR-Ex, Paris 75015, France
* Corresponding author: email@example.com
Accepted: 17 December 2021
Called “bioblasts” in 1890, named “mitochondria” in 1898, baptized in 1957 as the “powerhouse of the cell” and christened in 1999 as the “motor of cell death”, mitochondria have been anointed in 2017 as “powerhouses of immunity”. In 1962, for the first time a causal link between mitochondria and human diseases was described, the genetic basis for which was revealed in 1988. The term “mitochondrial medicine” was coined in 1994. Research into mitochondria has been conducted ever since light microscopic studies during the end of the 19th century revealed their existence. To this day, new discoveries around this organelle and above all new insights into their fundamental role for human health and disease continue to surprise. Nowadays hardly any disease is known for which either the etiology or pathogenesis is not associated with malfunctioning mitochondria. In this second part of our review about recent developments in mitochondrial medicine we continue tracking and highlighting selected lines of mitochondrial research from their beginnings up to the present time. Mainly written for readers not familiar with this cell organelle, we hope both parts of our review will substantiate what we articulated over a decade ago, namely that the future of medicine will come through better understanding of the mitochondrion.
Key words: Mitochondrial Medicine / Aging / Microbiota / COVID-19 / Humanin / Reactive Oxygen Species
© V. Weissig & M. Edeas, Published by EDP Sciences, 2022
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.