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Figure 4


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Timescales of the collective activity in pancreas, measured as [Ca2+]c events in a typical day. Basal oscillatory activity with the period between 5 and 10 mins throughout the day (upper band) is increased after meals in a typical biphasic manner with a first peak followed by a plateau activity. On top of the basal oscillatory activity, a faster series of few seconds long bursts develops (middle band) as a temporal summation of unitary sub second events (lower band). The fast bursts can with a higher stimulation further summate to slow events of some tens of seconds during the plateau phase. Both, IP3 and ryanodine receptors contribute to the unitary events, however the former is dominant during the initial phase and the latter during the plateau phase.

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